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Polymicrogyria in standard poodles.
J Vet Intern Med. 2009 Jul-Aug;23(4):871-4
Authors: Jurney C, Haddad J, Crawford N, Miller AD, Winkle TJ, Vite CH, Sponenberg P, Inzana KD, Cook CR, Britt L, O’Brien DP
Background: Polymicrogyria is a disorder of cerebrocortical migration resulting in increased numbers of small, disorganized gyri. This disorder occurs in Standard Poodles and in cattle. Objectives: To describe the clinical, electroencephalographic, imaging, and histopathologic features in poodles with polymicrogyria. Animals: Five Standard Poodles with histologically confirmed polymicrogyria. Methods: Retrospective case series. Cases were obtained by personal communication with 1 of 2 authors (TJVW, DPO). Results: All dogs had cortical blindness and other neurologic abnormalities including gait and behavioral changes. Magnetic resonance imaging of 3 dogs showed multiple disorganized gyri, which were especially apparent on T2-weighted dorsal plane images. Electroencephalogram (EEG) of 1 dog revealed epileptiform discharges, including both spike and spike and wave discharges with voltage maximum potentials over the parietal/occipital region. The EEG supported that the repetitive behavior displayed by the dog was a complex partial motor seizure. One dog had concurrent hydrocephalus. All dogs had occipital lobe involvement and 2 dogs had involvement of other lobes. Clinical Importance: The cases presented here demonstrate a larger age range (7 weeks to 5 years) and a decreased frequency of associated hydrocephalus when compared with the previous report.
PMID: 19566852 [PubMed – in process]
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