Here’s a case of a 5-year-old male Dogue de Bordeaux who was anorexic and lethargic. Bloodwork showed hematocrit 52.3%, platelets 84,000, WBC 6,350. BUN 44, creatinine 2.2, PO4 5.0, Ca 16.0, cholesterol 443, Na 159. USG – 1.015.
Teaching and learning about veterinary diagnostic imaging.
Here’s a case of a 5-year-old male Dogue de Bordeaux who was anorexic and lethargic. Bloodwork showed hematocrit 52.3%, platelets 84,000, WBC 6,350. BUN 44, creatinine 2.2, PO4 5.0, Ca 16.0, cholesterol 443, Na 159. USG – 1.015.
There is increased soft tissue opacity in the cranial mediastinum on both lateral projections. The cranial mediastinum is also widened on the d/v projection. The trachea is elevated on both laterals suggesting a cranial mediastinal mass. The esophagus is mildly dilated with air on both projections. The remainder of the intrathoracic structures appear normal.
High grade lymphoma
Mediastinal masses can be difficult to diagnose in large breed dogs that usually have a fair amount of fat in the cranial mediastinum. The persistent elevation of the trachea is confirmatory in this case. Ultrasound can be useful in distinguishing between a cranial mediastinal mass and fat, especially if there is contact with the chest wall or there is pleural effusion.
The esophageal dilation makes thymoma a top differential as it can cause myasthenia gravis and megaesophagus. This mass was caused by enlarged cranial mediastinal lymph nodes from high grade lymphoma.
This dog also had hypercalcemia of malignancy. Certain types of lymphoma can produce a molecule called parathyroid hormone related peptide (PTHrP), which increases calcium levels by mimicking PTH. Once aggressive fluid treatment was implemented and chemotherapy was administered (Elspar), the calcium level began to decrease. Approximately one day after the calcium level decreased, the azotemia began to resolve. The fluids were weaned over the next three days and were discontinued just prior to discharge.
pbargcar says
Allison, besides the cranial mediastinal mass, I see the thoracic portion of the CVC with an unsual shape, would you agree? I have never seen that before and I am wondering if this could mean something or not. Thank you
Allison Zwingenberger says
The thoracic caudal vena cava often tapers toward the diaphragm and sometimes curves slightly. It depends on the cardiac cycle and the degree of inflation. In this case, I think it’s within normal limits. Take a look at some other examples of thoracic radiographs to see the range of normal variations. Hope that helps!
kburton says
I worry I miss cran mediastinal masses by assuming the opacity is just due to overlying thoracic musculature… How can I distinguish the two? Thanks
Allison Zwingenberger says
There are a couple of imaging signs that will help to identify an enlarged cranial mediastinum including elevation of the trachea, and widening of the mediastinum on the dorsoventral projection (more than the width of the vertebral column). You can see both of these signs in this case. Dogs with excess fat in the mediastinum and certain breeds will have increased opacity without elevation of the trachea, but these can be difficult to be certain. A thoracic ultrasound or CT can be used to determine if there is truly a mass.